Deionized water equipment to ensure drinking water safety
Toxicity to laboratory animals and its relationship with human health
For different forms of manganese, the range of oral LDg is between 400 and 830 mg/kg. Manganese in deionized water equipment mainly harms the central nervous system, and can cause poisoning symptoms such as decadence, increased muscle tone, tremor and mental retardation. If each large exposure dose is between 1~150mg/kg, experimental rats and mice will have some symptoms of nervous system damage, mainly including changes in neurotransmitting mediators and enzyme levels in the brain. Sometimes these changes are accompanied by clinical symptoms, such as movement disorders and changes in activity levels. Chronic intake of 1 to 2 mg of manganese per kilogram of body weight per day will change the appetite of rabbits, pigs and cattle and reduce the synthesis of hemoglobin. Prolonged exposure to manganese will temporarily affect the levels of biogenic amines and the activities of dopamine B-hydroxylase and monoamine oxidase in the rat brain. The monkeys were given 25mg/kg of manganese orally every day for 18 months, and the monkeys were observed to become weak and dull. Chronic manganese exposure in our institute can cause changes in reproductive function. Although some animal studies have shown that the right amount of manganese has a certain anti-cancer effect, but excessive intake of manganese will increase the incidence of tumors. The decoction age and the amount of care resources are OK.
3. Determination of the limit value in drinking water
Xingyang Tianyi. 6-person joint heavy material Yatianshu, a human flesh can take up to 20mg of manganese per day without obvious morbidity. If calculated according to the intake of 12mg/d, a 60kg adult can receive 0.2mg/kg of manganese per day. In general, only 20% of manganese intake is provided by drinking water. Considering that the bioavailability of manganese in water may increase and the tentative uncertainty factor is 3, the health-based mass concentration limit of manganese in water is calculated based on this. However, it should be noted that although this limit is sufficient to protect human health, this content will cause precipitation and make the water turbid. Therefore, when the manganese content is less than 0.1mg/L, it will cause users to be concerned about the water quality. Quite satisfied.
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